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QHG improves myocardial markers and serum inflammatory factors in sepsis, but this effect can be reversed by MasR/PI3K-AKT-mTOR pathway inhibitors ( n = 3). ( A ) The levels of serum myocardial markers <t>cTnT</t> <t>and</t> <t>BNP.</t> ( B ) The levels of serum inflammatory factors TNF-α and IL-1β. Data are presented as mean ± SEM. * P < 0.05, ns : no significant difference.
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QHG improves myocardial markers and serum inflammatory factors in sepsis, but this effect can be reversed by MasR/PI3K-AKT-mTOR pathway inhibitors ( n = 3). ( A ) The levels of serum myocardial markers cTnT and BNP. ( B ) The levels of serum inflammatory factors TNF-α and IL-1β. Data are presented as mean ± SEM. * P < 0.05, ns : no significant difference.

Journal: Scientific Reports

Article Title: The therapeutic effect of Qishen Huoxue Granule on myocardial injury in sepsis rats and its underlying mechanism via suppressing excessive autophagy

doi: 10.1038/s41598-025-18229-x

Figure Lengend Snippet: QHG improves myocardial markers and serum inflammatory factors in sepsis, but this effect can be reversed by MasR/PI3K-AKT-mTOR pathway inhibitors ( n = 3). ( A ) The levels of serum myocardial markers cTnT and BNP. ( B ) The levels of serum inflammatory factors TNF-α and IL-1β. Data are presented as mean ± SEM. * P < 0.05, ns : no significant difference.

Article Snippet: The serum was collected and supernatants were obtained by centrifugation at 4°C for 10 min. Then, according to the instructions of ELISA kits, ELISA detected the rats cTnT (CSB-E16443r, Cusabio, USA), BNP (CSB-E08594r, Cusabio, USA), TNF-α (BMS625, Thermo, USA), IL-1β (RTA 00, R & D, USA).

Techniques: